I followed up with my doctor after receiving the news Monday that I had tested negative for the Beta3 Integrin protein needed for the adhesion of the embryo. Although I had tested negative for the protein at the time of the test, the doctor said that I may actually not be 100% negative for the protein, I may just have it later in my cycle than is necessary for embryo implantation. He basically told me that my "endometrium is out of phase with my glandular stromal dyssynchrony" meaning that my lining is not synchronized with my hormone levels, but they can fix this. He said it's actually inconclusive as to whether or not I have the protein.
He said that they could either treat it as I am negative for the protein, or repeat a cycle, put me on progesterone and redo the biopsy. He said that there is no downside to treating me as though it is for sure a negative. He also said that my RPL (recurrent pregnancy loss) came back negative, meaning nothing was found so that is great. This Beta3 Protein deficiency is the only thing that they can find that is wrong. He saying that my fertile period is at one time and the embryos are coming at another and it's not lining up. He also said that is possibly why I miscarried in the past. He said that they did not identify if I have an implantation issue, but that we should move forward with treating me for the Beta3 Integrin negative protocol.
At first he said that I would be able to fit in the May cycle, but then we realized that I would not fit into that cycle. In June there is no cycle because he will be out of town, so that is another reason why I have to wait until July. He also said that some doctors say it's "hocus pocus" and others say "it's absolutely the reason people don't get pregnant" when I asked why my previous doctor seemed so unconcerned with this when I asked about it.
So, here is my plan for IVFx4:
April 15th - Last BCP
Have a period
April 22nd - New BCP
May 8th - Self-administered intramuscular Lupron Depot injection good for 4 weeks.
May 14th - Last BCP
Have a period
3 days after my period start Aygestin for 6 weeks which is for the protein
1st-2nd week of June - Self-administered intramuscular Lupron Depot injection good for 4 weeks.
2nd week of July - baseline/labs
Although July isn't a really a long way off, when you're counting the days and months it can really seem like an eternity. I'm going to make each of these days in my plan my mini-milestones. Although "last BCP" seems relatively insignificant, if I mark it on my calendar and check each of these dates off, these months should go by quickly. I think between that and moving into the house, summer will go by quickly and we will be nearing July before we know it.
If you guys recall, this is almost to the exact date, what happened to me last year. On April 11, 2014, I went to my previous doctor to have my final baseline before IUI #3, he told me for a second time I had been overstimulated and that the cycle would have to be canceled and I should consider IVF. Unfortunately I was too late to fit into the May cycle so I had to wait until July. So I already know that if I made it last year and worked through the days and the time passed once, I can certainly get through it again. I really am so happy to have an answer after all of these years. I have already waited and longed for this for 3.5 years so another 3 months is really nothing compared to that and if it will get us our miracle, than it is certainly worth the wait!
Although I am chomping at the bit to start this, I know that I need to put it on the back burner, continue with my protocol as the doctor has ordered, and enjoy life. We are so blessed to have almost finished building our dream home and we have so many other wonderful things to be thankful for. We've got weddings, we've got birthdays, we've got the bike out and ready to ride, and we finally have beautiful weather to enjoy so I am planning on keeping myself as occupied as possible and enjoying my life! I will keep the positive energy flowing and the positive vibrations vibin'!